You need to check the "lock against scanning" checkbox next to the serial number field to ensure that your manual changes are not overwritten.
In terms of computer name changes: currently, the correct way to rename a computer is to first rename it in Lansweeper and then rename the machine itself. You can rename a computer by browsing to its Lansweeper webpage and then hitting the Edit Asset button (5.0) or by right-clicking on it in the Lansweeper configuration console under Lansweeper/Scanned Computers and selecting Rename Computer (4.2).
When the machine is rescanned, its existing database entry will then simply be updated. If you don’t first rename the machine in Lansweeper, a new database entry will be generated for it. Lansweeper currently uses the combination domain name/computer name as a unique Windows computer identifier.