I would first suggest to try this report:
Select Top 100 Percent tblComputers.Computername, tblOperatingsystem.Description, tblComputers.Domain, Count(tblAutorun.AutorunID) As [Total Autorun] From tblComputers Left Join tblOperatingsystem On tblComputers.Computername = tblOperatingsystem.Computername Inner Join web40repActiveComputers On web40repActiveComputers.Computername = tblComputers.Computername Inner Join tblAutorun On tblComputers.Computername = tblAutorun.Computername Group By All tblComputers.Computername, tblOperatingsystem.Description, tblComputers.Domain Having Count(tblAutorun.AutorunID) > 100 Order By Count(tblAutorun.AutorunID) Desc
Misconfigured autorun on some computers is often the problem.