I think I figured it out based on another post I saw here (Solved: Report for missing registry keys - Lansweeper Community - 58474).
I did want to post what I have used below if it helps anyone else. Or, if there is a better way of handling something similar let me know. I am using this to deploy packages to PC's that are missing a particular registry key. The deployment will create this key causing the entry to fall off of the report preventing redeployment.
Select Top 1000000 tblAssets.AssetID,
tblAssets.AssetName,
tsysAssetTypes.AssetTypeIcon10 As icon,
tblAssets.IPAddress,
tblAssets.Lastseen,
tblAssets.Lasttried,
tblADComputers.OU
From tblAssets
Inner Join tblAssetCustom On tblAssets.AssetID = tblAssetCustom.AssetID
Inner Join tsysAssetTypes On tsysAssetTypes.AssetType = tblAssets.Assettype
Inner Join tblADComputers On tblAssets.AssetID = tblADComputers.AssetID
Where tblAssets.AssetID Not In (Select tblAssets.AssetID
From tblAssets Inner Join tblRegistry On tblAssets.AssetID =
tblRegistry.AssetID
Where tblRegistry.Regkey Like '%CURRENT%USER%\SOFTWARE\Folder\Folder' And
tblRegistry.Valuename = 'Key Version' And
tblRegistry.Value Like '5.5.5') And tblAssets.Lastseen <> '' And
tblADComputers.OU Like '%OU=Organizational Unit%' And tblAssetCustom.State = 1
Group By tblAssets.AssetID,
tblAssets.AssetName,
tsysAssetTypes.AssetTypeIcon10,
tblAssets.IPAddress,
tblAssets.Lastseen,
tblAssets.Lasttried,
tblADComputers.OU
Order By tblAssets.AssetName
I did generalize certain things like the Key and OU before posting.